Synthesis of N-heterocyclic analogs of natural muricadienin — promising antitumor agents

Synthesis of N-heterocyclic analogs of natural muricadienin — promising antitumor agents Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2024, Volume: 73, Number: 5, Pages: 1408-1416 Pages count : 9 DOI: 10.1007/s11172-024-4259-x

Authors

Tuktarova R.A. ¹ , Dzhemileva L.U. ¹ , Dzhemilev U.M. ¹ , D’yakonov V.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A series of N-heterocyclic analogs of muricadienin, a precursor of various acetogenins, were synthesized, and their biological activity was studied. It was revealed that the linking group between the N-methylpyrazole/imidazole part and the hydrophobic alkadienyl chain affects the ability of these compounds to induce apoptosis and cause cell cycle arrest. Compound 3b showed the highest cytotoxic activity.

Tuktarova R.A. , Dzhemileva L.U. , Dzhemilev U.M. , D’yakonov V.A.
Synthesis of N-heterocyclic analogs of natural muricadienin — promising antitumor agents
Russian Chemical Bulletin. 2024. V.73. N5. P.1408-1416. DOI: 10.1007/s11172-024-4259-x WOS Scopus OpenAlex

Web of science:	WOS:001252371600028
Scopus:	2-s2.0-85196521693
OpenAlex:	W4399899326

DB	Citing
OpenAlex	4
Scopus	4
Web of science	4