Iodine-promoted synthesis of pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides

Iodine-promoted synthesis of pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides Full article

Journal

Organic Chemistry Frontiers
ISSN: 2052-4110 , E-ISSN: 2052-4129

Output data

Year: 2020, Volume: 7, Number: 13, Pages: 1640-1646 Pages count : 7 DOI: 10.1039/d0qo00476f

Authors

Komendantova Anna S. ¹ , Lyssenko Konstantin A. ^2,3 , Zavarzin Igor V. ¹ , Volkova Yulia A. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., Moscow, Russian Federation
2	G.V. Plekhanov Russian University of Economics, 36 Stremyanny Per., Moscow 117997, Russian Federation
3	Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation

A novel approach to the synthesis of 3,4-dicarbonyl-substituted pyrazoles from a wide range of 1,3-dicarbonyl compounds and oxamic acid thiohydrazides was developed via iodine-promoted cascade imination/halogenation/cyclization/ring contraction reaction accompanied by sulfur elimination. This procedure provides a highly efficient and facile route to functionalized pyrazoles from readily available substrates under mild reaction conditions.

Komendantova A.S. , Lyssenko K.A. , Zavarzin I.V. , Volkova Y.A.
Iodine-promoted synthesis of pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides
Organic Chemistry Frontiers. 2020. V.7. N13. P.1640-1646. DOI: 10.1039/d0qo00476f WOS Scopus OpenAlex

≡ Web of science:	WOS:000544472100007
≡ Scopus:	2-s2.0-85092039143
≡ OpenAlex:	W3030603839