Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2020, Volume: 30, Number: 4, Pages: 424-426 Pages count : 3 DOI: 10.1016/j.mencom.2020.07.006

Authors

Vereshchagin Anatoly N. ¹ , Frolov Nikita A. ¹ , Konyuhova Valeria Yu. ¹ , Dorofeeva Evgeniya O. ¹ , Hansford Karl A. ² , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C8H17 aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.

Vereshchagin A.N. , Frolov N.A. , Konyuhova V.Y. , Dorofeeva E.O. , Hansford K.A. , Egorov M.P.
Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer
Mendeleev Communications. 2020. V.30. N4. P.424-426. DOI: 10.1016/j.mencom.2020.07.006 WOS Scopus OpenAlex

Web of science:	WOS:000557884000006
Scopus:	2-s2.0-85088954095
OpenAlex:	W3047535961

DB	Citing
OpenAlex	17
Scopus	12
Web of science	11