Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells

Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2020, Volume: 56, Number: 6, Pages: 722-726 Pages count : 5 DOI: 10.1007/s10593-020-02722-4

Authors

Vil Vera A. ¹ , Yaremenko Ivan A. ¹ , Fomenkov Dmitri I. ¹ , Levitsky Dmitri O. ² , Fleury Fabrice ² , Terent’ev Alexander O. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia
2	Mechanism and Regulation of DNA Repair Team, Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, 44322, Nantes, France

Bridged 1,2,4,5-tetraoxanes were prepared using available acidic ion exchange resin with high yields despite the possibility of peroxide decomposition under heterogeneous conditions. The bridged tetraoxanes demonstrated high cytotoxicity against HeLa cancer cells in vitro, which in some cases was higher than that of cisplatin, artesunate, and dihydroartemisinin.

Vil V.A. , Yaremenko I.A. , Fomenkov D.I. , Levitsky D.O. , Fleury F. , Terent’ev A.O.
Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells
Chemistry of Heterocyclic Compounds. 2020. V.56. N6. P.722-726. DOI: 10.1007/s10593-020-02722-4 WOS Scopus OpenAlex

≡ Web of science:	WOS:000552171100002
≡ Scopus:	2-s2.0-85089015007
≡ OpenAlex:	W3044301501