Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment

Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment Review

Journal

Reviews and Advances in Chemistry
ISSN: 2634-8284

Output data

Year: 2024, Volume: 14, Number: 1, Pages: 16-21 Pages count : 6 DOI: 10.1134/s2634827624600105

Authors

Raskil’dina G.Z. ¹ , Borisova Yu.G. ¹ , Vereshchagin A.N. ² , Detusheva E.V. ^2,3 , Sultanova R.M. ¹ , Zlotskii S.S. ¹

Affiliations

1	Ufa State Petroleum Technical University, 450064, Ufa, Russia
2	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia
3	State Scientific Center for Applied Microbiology, 142279, Obolensk, Moscow oblast, Russia

Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by 1H and 13C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed. Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.

Raskil’dina G.Z. , Borisova Y.G. , Vereshchagin A.N. , Detusheva E.V. , Sultanova R.M. , Zlotskii S.S.
Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment
Reviews and Advances in Chemistry. 2024. V.14. N1. P.16-21. DOI: 10.1134/s2634827624600105 OpenAlex

OpenAlex:

W4400007917

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