Advances in the chemistry of 1,2,3,4-tetrazines

Advances in the chemistry of 1,2,3,4-tetrazines Review

Journal

Russian Chemical Reviews
ISSN: 1468-4837 , E-ISSN: 0036-021X

Output data

Year: 2023, Volume: 92, Number: 8, Article number : RCR5089, Pages count : DOI: 10.59761/rcr5089

Authors

Klenov Mikhail Sergeevich ¹ , Voronin Aleksey Aleksandrovich ¹ , Churakov Aleksandr Mikhailovich ¹ , Tartakovsky Vladimir Alexandrovich ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

The experimental and theoretical chemistry of 1,2,3,4-tetrazines have been actively studied in the last 20 years. The increasing interest in this class of compounds is due to the fact that the 1,2,3,4-tetrazine ring is a promising building block for the development of energetic and physiologically active compounds. The review considers various types of 1,2,3,4-tetrazines including completely unsaturated nonannulated tetrazines and their N-oxides; nitrogen-substituted tetrazines; annulated tetrazines with a nitrogen atom common to two heterocycles; 1,2,3,4-tetrazine 1,3-dioxides fused to benzene, pyridine, 1,2,3-triazole or 1,2,5-oxadiazole ring; and also 1,2,3,4-tetrazine 1,3-dioxide fused to one more 1,2,3,4-tetrazine 1,3-dioxide ring. Methods of synthesis and reactivity of these compounds, their crystallographic features, spectral characteristics and thermal stability are described. The results of quantum chemical studies for 1,2,3,4-tetrazine derivatives are presented. The prospects of using 1,2,3,4-tetrazines as energetic compounds are discussed.

Klenov M.S. , Voronin A.A. , Churakov A.M. , Tartakovsky V.A.
Advances in the chemistry of 1,2,3,4-tetrazines
Russian Chemical Reviews. 2023. Т.92. №8. RCR5089 . DOI: 10.59761/rcr5089 WOS Scopus OpenAlex

≡ Web of science:	WOS:001061881700004
≡ Scopus:	2-s2.0-85172011645
≡ OpenAlex:	W4385541529