One-Pot Solvent-Involved Synthesis of 5-O-Substituted 5H-Chromeno[2,3-b]pyridines

One-Pot Solvent-Involved Synthesis of 5-O-Substituted 5H-Chromeno[2,3-b]pyridines Full article

Journal

Molecules
ISSN: 1420-3049

Output data

Year: 2023, Volume: 28, Number: 1, Article number : 64, Pages count : DOI: 10.3390/molecules28010064

Authors

Ryzhkova Yuliya E ¹ , Ryzhkov Fedor V ¹ , Elinson Michail N ¹ , Maslov Oleg I ¹ , Fakhrutdinov Artem N ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

Chromeno[2,3-b]pyridines are substances demanded in medicinal and material chemistry. PASE (pot, atom, and step economy) and in particular one-pot approaches are key green chemistry techniques that are applied for the synthesis of heterocyclic compounds. In this case, the PASE approach was extended with ‘component economy’, as solvent was used also as reactant (solvent-involved reaction). This approach was adopted for the one-pot synthesis of previously unknown O-substituted 5-alkoxy-5H-chromeno[2,3-b]pyridines via two-step transformation, namely the reaction of salicylaldehydes and malononitrile dimer, with the subsequent addition of alcohol. The mechanistic studies revealed the possibility of concurrent reaction. The studies aided in optimizing the reaction conditions for the best yields (77–93%). Thus, the one-pot reaction proceeds efficient and quickly, and the work-up procedure (only simple filtering) is very convenient. The structure of synthesized chromeno[2,3-b]pyridines was confirmed by 2D NMR spectroscopy.

Ryzhkova Y.E. , Ryzhkov F.V. , Elinson M.N. , Maslov O.I. , Fakhrutdinov A.N.
One-Pot Solvent-Involved Synthesis of 5-O-Substituted 5H-Chromeno[2,3-b]pyridines
Molecules. 2023. V.28. N1. 64 . DOI: 10.3390/molecules28010064 WOS Scopus OpenAlex

≡ Web of science:	WOS:000909214400001
≡ Scopus:	2-s2.0-85145690548
≡ OpenAlex:	W4313574187