Asymmetric Addition of Allomaltol to Chalcones and Bis(arylidene)acetones: En Route to Chiral Drugs Научная публикация
| Журнал |
Advanced Synthesis & Catalysis
ISSN: 1615-4169 , E-ISSN: 1615-4150 |
||
|---|---|---|---|
| Вых. Данные | Год: 2025, Том: 367, Номер: 1, Номер статьи : e202400817, Страниц : DOI: 10.1002/adsc.202400817 | ||
| Авторы |
|
||
| Организации |
|
Реферат:
The synthesis of enantiomerically enriched γ-oxobutyric acid and succinic acid derivatives based on asymmetric conjugate addition of allomaltol to chalcones or bis(arylidene)acetones in the presence of readily available and recoverable C2-symmetric tertiary amine-squaramide organocatalyst has been developed. Ru(III)-catalyzed oxidative transformation of pyran-4-ones bearing the α,β-enone unit to enantiomerically enriched succinic acid derivatives via a one-pot oxidative fragmentation of both the γ-pyrone ring and activated C=C bond has been elaborated. The developed methodology was applied for scalable asymmetric synthesis of GABAB receptor agonists precursors, RAR receptor agonists and monoaminooxidase (MAO) inhibitors.
Библиографическая ссылка:
Kovalevsky R.A.
, Kucherenko A.S.
, Zlotin S.G.
Asymmetric Addition of Allomaltol to Chalcones and Bis(arylidene)acetones: En Route to Chiral Drugs
Advanced Synthesis & Catalysis. 2025. V.367. N1. e202400817 . DOI: 10.1002/adsc.202400817 WOS OpenAlex
Asymmetric Addition of Allomaltol to Chalcones and Bis(arylidene)acetones: En Route to Chiral Drugs
Advanced Synthesis & Catalysis. 2025. V.367. N1. e202400817 . DOI: 10.1002/adsc.202400817 WOS OpenAlex
Идентификаторы БД:
| Web of science: | WOS:001337155500001 |
| OpenAlex: | W4402286850 |
Цитирование в БД:
Пока нет цитирований