Advances in radical peroxidation with hydroperoxides

Advances in radical peroxidation with hydroperoxides Review

Journal

Beilstein Journal of Organic Chemistry
ISSN: 2195-951X , E-ISSN: 1860-5397

Output data

Year: 2024, Volume: 20, Pages: 2959-3006 Pages count : 48 DOI: 10.3762/bjoc.20.249

Authors

Bityukov Oleg V ¹ , Serdyuchenko Pavel Yu ¹ , Kirillov Andrey S ¹ , Nikishin Gennady I ¹ , Vil' Vera A ¹ , Terent'ev Alexander O ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation.

Organic peroxides have become sought-after functionalities, particularly following the multi-tone consumption in polymer production and success in medicinal chemistry. The selective introduction of a peroxide fragment at different positions on the target molecule is a priority in the modern reaction design. The pioneering Kharasch–Sosnovsky peroxidation became the basic universal platform for the development of peroxidation methods, with its great potential for rapid generation of complexity due to the ability to couple the resulting free radicals with a wide range of partners. This review discusses the recent advances in the radical Kharasch-type functionalization of organic molecules with OOR fragment including free-component radical couplings. The discussion has been structured by the type of the substrate of radical peroxidation: C(sp3)–H substrates; aromatic systems; compounds with unsaturated C–C or C–Het bonds.

Bityukov O.V. , Serdyuchenko P.Y. , Kirillov A.S. , Nikishin G.I. , Vil' V.A. , Terent'ev A.O.
Advances in radical peroxidation with hydroperoxides
Beilstein Journal of Organic Chemistry. 2024. V.20. P.2959-3006. DOI: 10.3762/bjoc.20.249 WOS OpenAlex

Web of science:	WOS:001359938700001
OpenAlex:	W4404487997

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