Somatic Antigens of Shigella | Sciact - научная деятельность

Somatic Antigens of Shigella Научная публикация

Журнал

European Journal of Biochemistry
ISSN: 0014-2956 , E-ISSN: 0945-5795

Вых. Данные

Год: 1976, Том: 66, Номер: 3, Страницы: 559-566 Страниц : 8 DOI: 10.1111/j.1432-1033.1976.tb10582.x

Авторы

DMITRIEV Boris A. ¹ , KNIREL Yuriy A. ¹ , KOCHETKOV Nikolay K. ¹ , HOFMAN Irihna L. ²

Организации

1	Institut Organicheskoj Khimii im. N. D. Zelinskogo, Akademia Nauk, Leninskij Prospekt 47, Moskva, U.S.S.R. 117913
2	Institut Mikrobiologii i Epidemiologii Minzdrava, Upensky per. 12, Moskva K-6, U.S.S.R.

The O-specific polysaccharide obtained from the lipopolysaccharide of Shigella dysenteriae type 1 (Shigella shiga) by mild acid hydrolysis followed by fractionation on Sephadex G-50 was found to be identical to that described by Morgan's group and was composed of l-rhamnose, d-galactose and N-acetyl-d-glucosamine in a ratio 2:1:1. On the basis of methylation analysis data the polysaccharide was proved to be a linear chain of monosaccharide residues in pyranose forms substituted at position 3, except for that of galactose substituted at position 2. Selective cleavage, based on the N-deacetylation reaction of the polymer, together with determination of linkage configurations by chromic anhydride oxidation showed that the O-specific polysaccharide is built up of repeating tetrasaccharide units whose proposed structure is given below -3)-α-l-Rhap(1–3)-α-l-Rhap(1–2)-α-d-Galp(1–3)-α-d-GlcNAcp(1- where Rhap = rhamnopyranose, Galp = galactopyranose, and GlcNAcp =N-acetyl-glucosamine. The present findings confirmed the considerations of Heidelberger on the substitution patterns of l-rhamnose and d-galactose residues from the results of serological studies.

DMITRIEV B.A. , KNIREL Y.A. , KOCHETKOV N.K. , HOFMAN I.L.
Somatic Antigens of Shigella
European Journal of Biochemistry. 1976. V.66. N3. P.559-566. DOI: 10.1111/j.1432-1033.1976.tb10582.x OpenAlex

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