Abstract: Electrocatalytic transformation of aldehydes with two equivalents of 1,3-diethyl-2-thiobarbituric acid has been carried out in alcohols in an undivided cell in the presence of sodium halides with the selective formation of the substituted 5,5'-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) in 87–98% yields and with 870–980% current efficiency. This new one-pot electrochemically induced tandem Knoevenagel–Michael process is a simple and efficient approach to substituted 5,5'-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) containing two 1,3-diethyl-2-thiobarbituric acid fragments separated by C-aryl-substituted spacer, which are promising compounds for different biomedical applications, including anticonvulsant, antiAIDS agents and anti-inflammatory remedies. Theoretical studies were carried out to investigate the interaction of the synthesized compounds with beef and human catalases.

Cite: Elinson M.N. , Vereshchagin A.N. , Ryzhkova Y.E. , Karpenko K.A. , Ryzhkov F.V. , Egorov M.P.
Electrocatalytic tandem assembly of aldehydes with 2-thiobarbituric acid into 5,5'-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) and evaluation of their interaction with catalases
Chemistry of Heterocyclic Compounds. 2021. V.57. N3. P.274-283. DOI: 10.1007/s10593-021-02904-8 WOS Scopus OpenAlex

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Web of science:	WOS:000632748000003
Scopus:	2-s2.0-85103204731
OpenAlex:	W3150369970

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