Novel C2-symmetric phenylglycine derivatives as organocatalysts of the Michael reaction between nitroalkenes and ketones Full article
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Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285 |
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| Output data | Year: 2021, Volume: 70, Number: 5, Pages: 885-889 Pages count : 5 DOI: 10.1007/s11172-021-3163-x | ||
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Abstract:
A comprehensive study of the activity of the amide-type organocatalysts based on (R)- and (S)-phenylglycine and 1,2-di(2-pyridyl)-1,2-diaminoethane in the asymmetric Michael reaction between various nitroalkenes and ketones was carried out. The products of the studied reactions were formed in up to 99% yield, with syn diastereoselectivity (dr) >20: 1 and enantiomeric excess of up to 93% ee for syn-isomer. The organocatalysts can be regenerated and reused in at least seven reaction cycles.
Cite:
Kostenko A.A.
, Kuznetsova O.Y.
, Kucherenko A.S.
, Zlotin S.G.
Novel C2-symmetric phenylglycine derivatives as organocatalysts of the Michael reaction between nitroalkenes and ketones
Russian Chemical Bulletin. 2021. V.70. N5. P.885-889. DOI: 10.1007/s11172-021-3163-x WOS Scopus OpenAlex
Novel C2-symmetric phenylglycine derivatives as organocatalysts of the Michael reaction between nitroalkenes and ketones
Russian Chemical Bulletin. 2021. V.70. N5. P.885-889. DOI: 10.1007/s11172-021-3163-x WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:000657311100011 |
| Scopus: | 2-s2.0-85107078651 |
| OpenAlex: | W3167726145 |