Synthesis of 1,3-dialkyl-4-[(arylmethylidene)amino]glycolurils

Synthesis of 1,3-dialkyl-4-[(arylmethylidene)amino]glycolurils Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2021, Volume: 57, Number: 6, Pages: 646-655 Pages count : 10 DOI: 10.1007/s10593-021-02963-x

Authors

Serkov Sergei А. ¹ , Es’kova Marina А. ^1,2 , Sigay Natalya V. ¹ , Kostikova Natalya N. ¹ , Volkhina Tatyana N. ^2,3 , Kolotyrkina Natalya G. ¹ , Gazieva Galina А. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia;
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
3	D. Mendeleev University of Chemical Technology of Russia; Moscow Russia

A method for the synthesis of 1,3-dialkyl-4-[(arylmethylidene)amino]glycolurils was developed based on nucleophilic substitution of the sulfur atom with the oxygen atom in the corresponding thioglycolurils via alkylation of the latter followed by acid hydrolysis of alkylsulfanyl derivatives of thioglycolurils, both with the isolation of alkylsulfanyl intermediates and by the one-pot method. The structure of the synthesized compounds was confirmed by X-ray structural analysis of several examples.

Serkov S.А. , Es’kova M.А. , Sigay N.V. , Kostikova N.N. , Volkhina T.N. , Kolotyrkina N.G. , Gazieva G.А.
Synthesis of 1,3-dialkyl-4-[(arylmethylidene)amino]glycolurils
Chemistry of Heterocyclic Compounds. 2021. V.57. N6. P.646-655. DOI: 10.1007/s10593-021-02963-x WOS Scopus OpenAlex

≡ Web of science:	WOS:000667624000001
≡ Scopus:	2-s2.0-85110380739
≡ OpenAlex:	W3174461780