Selective cleavage of glycosidic linkages: Studies with the O-specific polysaccharide from Shigella dysenteriae type 3 Full article
| Journal |
Carbohydrate Research
ISSN: 1873-426X , E-ISSN: 0008-6215 |
||
|---|---|---|---|
| Output data | Year: 1975, Volume: 40, Number: 2, Pages: 365-372 Pages count : 8 DOI: 10.1016/s0008-6215(00)82617-8 | ||
| Authors |
|
||
| Affiliations |
|
Abstract:
Treatment of the O-specific polysaccharide from Shigella dysenteriae Type 3 with hydrazine in the presence of hydrazine sulphate resulted in quantitative N-deacetylation with the formation of a modified polysaccharide containing free amino groups. Oxidation of the modified polysaccharide with periodate did not destroy the 2-amino-2-deoxygalactose residues, thus indicating that they were substituted at position 3. Acid hydrolysis of the modified polysaccharide afforded 3-O-(2-amino-2-deoxy-β-D-galactopyranosyl)-D-galactose, which was identified as the N-acetyl derivative. Deamination of the modified polysaccharide with nitrous acid cleaved the 2-amino-2-deoxy-D-galactopyranosyl linkages to give a pentasaccharide as the major product, which appeared to be the modified chemical repeating unit of the O-specific polysaccharide.
Cite:
Dmitriev B.A.
, Knirel Y.A.
, Kochetkov N.K.
Selective cleavage of glycosidic linkages: Studies with the O-specific polysaccharide from Shigella dysenteriae type 3
Carbohydrate Research. 1975. V.40. N2. P.365-372. DOI: 10.1016/s0008-6215(00)82617-8 WOS Scopus OpenAlex
Selective cleavage of glycosidic linkages: Studies with the O-specific polysaccharide from Shigella dysenteriae type 3
Carbohydrate Research. 1975. V.40. N2. P.365-372. DOI: 10.1016/s0008-6215(00)82617-8 WOS Scopus OpenAlex
Identifiers:
| Web of science: | WOS:A1975W308500015 |
| Scopus: | 2-s2.0-0016491141 |
| OpenAlex: | W2057412212 |