Abstract: The polysaccharide component obtained from the lipopolysaccharide of Shigella dysenteriae type 6 was subjected to mild hydrolysis with acid, and the products were fractionated on Sephadex G-50. An acidic hexosaminoglycan and a core oligosaccharide fraction were obtained, the former containing d-glucose, d-galactose, 2-acetamido-2-deoxy-d-galactose (in the ratios 1:1:1), and an unidentified acidic component (X). The hexosaminoglycan was N-deacetylated and then hydrolysed and deaminated to give 3-O-(2-amino-2-deoxy-β-d-galactopyranosyl)-d-galactose (1), identified as the N-acetyl derivative (2), and 2,5-anhydro-3-O-(6-O-α-d-galactopyranosyl-α-d-glucopyranosyl)talitol (3). On the basis of the structure of 2 and the methylation-analysis data for the polysaccharide and 3, together with that for the determination of linkage configurations by chromic anhydride oxidation, the hexosaminoglycan is considered to have the repeating structure →3)-gb-d-GalNAcp-(1→3)-α-d-Galp-(1→6)-α-d-Glcp-(1→ .

Cite: Dmitriev B.A. , Knirel Y.A. , Kochetkov N.K. , Hofman I.L.
Selective cleavage of glycosidic linkages: studies with the polysaccharide component of Shigella dysenteriae type 6 lipopolysaccharide
Carbohydrate Research. 1975. V.44. N1. P.77-85. DOI: 10.1016/s0008-6215(00)84337-2 WOS Scopus OpenAlex

Identifiers:

Web of science:	WOS:A1975AX74500008
Scopus:	2-s2.0-0016563262
OpenAlex:	W2049064227

Citing:

DB	Citing
OpenAlex	23
Web of science	25
Scopus	21

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