4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2021, Volume: 2021, Number: 3, Article number : M1253, Pages count : DOI: 10.3390/m1253

Authors

Ogurtsov Vladimir A. ¹ , Rakitin Oleg A. ^1,2

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
2	Nanotechnology Education and Research Center, South Ural State University, 76 Lenina Avenue, 454080 Chelyabinsk, Russia

A novel 4-chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine was prepared by a rational and short two-step synthesis from commercially available ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate via 6-(chloromethyl)-1-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one. The structure of the synthesized compounds was established by elemental analysis, high-resolution mass-spectrometry, 1H, 13C-NMR and IR spectroscopy and mass-spectrometry. 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a convenient intermediate for various disubstituted 1-methyl-1H-pyrazolo[3,4-d]pyrimidines, which may be of interest as substances with useful pharmacological properties.

Ogurtsov V.A. , Rakitin O.A.
4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Molbank. 2021. V.2021. N3. M1253 . DOI: 10.3390/m1253 WOS Scopus OpenAlex

Web of science:	WOS:000700147200001
Scopus:	2-s2.0-85111569341
OpenAlex:	W3186285567

DB	Citing
OpenAlex	3
Scopus	3
Web of science	3