Novel Arylazo‐1,2,5‐oxadiazole Photoswitches: Synthesis, Photoisomerization and Nitric Oxide Releasing Properties

Novel Arylazo‐1,2,5‐oxadiazole Photoswitches: Synthesis, Photoisomerization and Nitric Oxide Releasing Properties Full article

Journal

ChemPhotoChem
ISSN: 2367-0932

Output data

Year: 2020, Volume: 4, Number: 12, Pages: 5346-5354 Pages count : 9 DOI: 10.1002/cptc.202000157

Authors

Zhilin Egor S. ¹ , Polkovnichenko Michael S. ^2,1 , Ananyev Ivan V. ³ , Fershtat Leonid L. ¹ , Makhova Nina N. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moskva, 119991 Leninsky Prospect, 47, Moscow, Russia
2	Department of Chemistry M. V. Lomonosov Moscow State University Moskva 119991 Leninskie Gory 1–3 Moscow Russia
3	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moskva, 119991 Vavilova str., 28, Moscow, Russia

A series of novel molecular photoswitches incorporating an aryldiazenyl moiety linked to a 1,2,5-oxadiazole (furazan) or 1,2,5-oxadiazole 2-oxide (furoxan) subunit was synthesized by a simple and step-economic chemical route. Upon visible light irradiation, (E)-arylazo-1,2,5-oxadiazoles underwent photoisomerization to the corresponding (Z)-isomers which are stable under ambient conditions. Structural factors affecting the photoswitching ability were also revealed. Synthesized photoswitches exhibited good performance due to the absence of fatigue or decomposition over at least ten cycles under air in a temperature range of 20–60 °C. NO donor properties of the synthesized arylazofuroxans were also evaluated in vitro and it was found that (Z)-arylazofuroxans released significantly larger amounts of NO than the corresponding (E)-isomers, which suggests strong potential of these molecular photoswitches in photopharmacology and other biomedical applications.

Zhilin E.S. , Polkovnichenko M.S. , Ananyev I.V. , Fershtat L.L. , Makhova N.N.
Novel Arylazo‐1,2,5‐oxadiazole Photoswitches: Synthesis, Photoisomerization and Nitric Oxide Releasing Properties
ChemPhotoChem. 2020. V.4. N12. P.5346-5354. DOI: 10.1002/cptc.202000157 WOS OpenAlex

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