Micronization of CL-20 using supercritical and liquefied gases

Micronization of CL-20 using supercritical and liquefied gases Full article

Journal

CrystEngComm
ISSN: 1466-8033

Output data

Year: 2020, Volume: 22, Number: 44, Pages: 7549-7555 Pages count : 7 DOI: 10.1039/d0ce01167c

Authors

Zharkov Mikhail N. ¹ , Kuchurov Ilya V. ¹ , Zlotin Sergei G. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prosp. 47, 119991 Moscow, Russian Federation

Liquid and supercritical CO2 and TFE have been systematically studied as media for CL-20 recrystallization to estimate their potential for the selective preparation of ultrafine particles. It has been found that the polymorphic composition of produced microcrystals can be efficiently controlled by the alteration of the solvent system and the micronization method used. Thus, the application of CO2 as an anti-solvent in both SAS and GAS methods results in the formation of α-CL-20–CO2 solvates, regardless of the process conditions. The use of TFE as an active medium for the GAS and RESS methods allows for selective preparation of uniform ultrafine β- or ε-CL-20 particles under mild conditions. The developed ε-CL-20 production method favorably differs from the known analogues by its tolerance to the quality of the initial substrate (crude CL-20), increased environmental and industrial safety, ease of product isolation, and the ability to control the particle morphology and crystalline phase.

Zharkov M.N. , Kuchurov I.V. , Zlotin S.G.
Micronization of CL-20 using supercritical and liquefied gases
CrystEngComm. 2020. V.22. N44. P.7549-7555. DOI: 10.1039/d0ce01167c WOS Scopus OpenAlex

Web of science:	WOS:000589871900005
Scopus:	2-s2.0-85096408442
OpenAlex:	W3087417362

DB	Citing
OpenAlex	21
Scopus	20
Web of science	19