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Four-component transformation of benzaldehydes, dimethylbarbituric acid, 4-hydroxy-6-methyl-2H-pyran-2-one, and morpholine into the unsymmetrical ionic scaffold with three different heterocyclic rings Full article

Journal Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285
Output data Year: 2022, Volume: 71, Number: 3, Pages: 464-473 Pages count : 10 DOI: 10.1007/s11172-022-3434-1
Authors Elinson M.N. 1 , Vereshchagin A.N. 1 , Ryzhkova Y.E. 1 , Karpenko K.A. 1 , Ushakov I.E. 2 , Maslov O.I. 1 , Egorov M.P. 1
Affiliations
1 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2 A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russian Federation

Abstract: A new type of the four-component tandem Knoevenagel—Michael reaction was discovered. The transformation of arylaldehydes, N,N′-dimethylbarbituric acid, 4-hydroxy-6-methyl-2H-pyran-2-one, and morpholine in alcohols, other organic solvents, and water without a catalyst or any other additives and without heating leads to the selective formation of a new substituted unsymmetric ionic scaffold with three different heterocyclic rings in 81–98% yields. The structure of the obtained compounds was confirmed by the data of X-ray diffraction analysis.
Cite: Elinson M.N. , Vereshchagin A.N. , Ryzhkova Y.E. , Karpenko K.A. , Ushakov I.E. , Maslov O.I. , Egorov M.P.
Four-component transformation of benzaldehydes, dimethylbarbituric acid, 4-hydroxy-6-methyl-2H-pyran-2-one, and morpholine into the unsymmetrical ionic scaffold with three different heterocyclic rings
Russian Chemical Bulletin. 2022. V.71. N3. P.464-473. DOI: 10.1007/s11172-022-3434-1 WOS Scopus OpenAlex
Identifiers:
Web of science: WOS:000787316800006
Scopus: 2-s2.0-85128812390
OpenAlex: W4224436596
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