Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo Научная публикация
| Журнал |
Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285 |
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| Вых. Данные | Год: 2022, Том: 71, Номер: 3, Страницы: 489-495 Страниц : 7 DOI: 10.1007/s11172-022-3438-x | ||||
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Реферат:
Nucleophilic substitution of the chlorine atom in 4,5-dichloro-1,2-dithiol-3-one using 1-thio-β-D-glucopyranose and its 2,3,4,6-tetra-O-acetyl derivative in acetonitrile resulted in two new 5-thioglucoside conjugates of 4-chloro-1,2-dithiol-3-one. The obtained thioglucosides showed cancer-preventive properties in a model of mouse epidermal JB6Cl41 P+ cells in soft agar, while one of them manifested antitumor activity in in vivo experiments in CD1 mice on a model of solid Ehrlich carcinoma. Both compounds were shown to inhibit basic AP-1-dependent transcriptional activity in murine JB6 Cl41 luc-AP-1 cells.
Библиографическая ссылка:
Fedorov S.N.
, Kuzmich A.S.
, Agafonova I.G.
, Sabutskii Y.E.
, Guzii A.G.
, Popov R.S.
, Ogurtsov V.A.
, Rakitin O.A.
, Polonik S.G.
Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo
Russian Chemical Bulletin. 2022. V.71. N3. P.489-495. DOI: 10.1007/s11172-022-3438-x WOS Scopus OpenAlex
Synthesis and study of thioglycoside conjugates of 4-chloro-1,2-dithiol-3-one as potential cancer-preventive substances in vitro and in vivo
Russian Chemical Bulletin. 2022. V.71. N3. P.489-495. DOI: 10.1007/s11172-022-3438-x WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000787316800010 |
| Scopus: | 2-s2.0-85128824462 |
| OpenAlex: | W4224678437 |