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Synthesis of branched heterooligosaccharides related to Aspergillus galactomannan containing short Galf side chains Научная публикация

Журнал Carbohydrate Research
ISSN: 1873-426X , E-ISSN: 0008-6215
Вых. Данные Год: 2025, Том: 549, Номер статьи : 109360, Страниц : DOI: 10.1016/j.carres.2024.109360
Авторы Rastrepaeva Darya A 1 , Argunov Dmitry A 1 , Puchkin Ilya A 1 , Yashunsky Dmitry V 1 , Krylov Vadim B 1 , Nifantiev Nikolay E 1
Организации
1 N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991, Moscow, Russian Federation.

Реферат: The members of a widespread Aspergillus fungi genus cause various diseases including the invasive aspergillosis with high morbidity and mortality rates, especially for immunosuppressed patients. One of the main carbohydrate structures on the surface of their cell wall is the galactomannan (GM) which is used in diagnostic kits for the detection of specific types of aspergillosis. However, limited specificity of currently available test systems urges the need for their further improvement. Herein we report the first synthesis of branched heterosaccharides related to GM and containing α-(1→2)-/α-(1→6)-linked tetramannoside backbone chain bearing one galactofuranoside unit or its β-(1→5)-linked dimer. The preparation of conjugates of the obtained spacered oligosaccharides with BSA is also performed to produce tools for the assessment the specificity of anti-Aspergillus immune response and to select antibodies suitable for the development of novel diagnostic kits that may discriminate distinct types of aspergillosis.
Библиографическая ссылка: Rastrepaeva D.A. , Argunov D.A. , Puchkin I.A. , Yashunsky D.V. , Krylov V.B. , Nifantiev N.E.
Synthesis of branched heterooligosaccharides related to Aspergillus galactomannan containing short Galf side chains
Carbohydrate Research. 2025. V.549. 109360 . DOI: 10.1016/j.carres.2024.109360 WOS OpenAlex
Идентификаторы БД:
Web of science: WOS:001393921600001
OpenAlex: W4405592864
Цитирование в БД: Пока нет цитирований
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