Green multicomponent approach to novel 5‐[(2H‐Pyran‐3‐yl)(aryl)methyl]‐1,3‐dimethylpyrimidines

Green multicomponent approach to novel 5‐[(2H‐Pyran‐3‐yl)(aryl)methyl]‐1,3‐dimethylpyrimidines Full article

Journal

Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193

Output data

Year: 2023, Volume: 60, Number: 4, Pages: 576-584 Pages count : 9 DOI: 10.1002/jhet.4609

Authors

Ryzhkova Yuliya E. ¹ , Kalashnikova Varvara M. ¹ , Fakhrutdinov Artem N. ¹ , Elinson Michail N. ¹

Affiliations

1	N. D. Zelinsky Institute of OrganicChemistry, Russian Academy of Sciences,Moscow, Russian Federation

The multicomponent green methodologies are an ideal instrument in organic synthesis. Environmentally benign, facile, and efficient multicomponent synthesis of [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidines by the reaction of aromatic aldehydes, N,N′-dimethylbarbituric acid and 4-hydroxy-6-methyl-2H-pyran-2-one employing simple and eco-friendly catalyst and solvent—sodium acetate and ethanol is reported. The reaction proceeds at reflux conditions with good and excellent yields (65%–97%). The isolation of final compounds does not require complex purification procedures. All novel synthesized compounds are characterized by 1H and 13C NMR spectroscopy, FT-IR and mass spectrometry, and elemental analysis. The [(2H-pyran-3-yl)(aryl)methyl]-1,3-dimethylpyrimidine structure was proven using 2D NMR spectroscopy methods.

Ryzhkova Y.E. , Kalashnikova V.M. , Fakhrutdinov A.N. , Elinson M.N.
Green multicomponent approach to novel 5‐[(2H‐Pyran‐3‐yl)(aryl)methyl]‐1,3‐dimethylpyrimidines
Journal of Heterocyclic Chemistry. 2023. V.60. N4. P.576-584. DOI: 10.1002/jhet.4609 WOS Scopus OpenAlex

≡ Web of science:	WOS:000896725000001
≡ Scopus:	2-s2.0-85143884613
≡ OpenAlex:	W4311117193