(3+2)-Cycloaddition of Donor–Acceptor Cyclopropanes with Thiocyanate: A Facile and Efficient Synthesis of 2-Amino-4,5-dihydrothiophenes

(3+2)-Cycloaddition of Donor–Acceptor Cyclopropanes with Thiocyanate: A Facile and Efficient Synthesis of 2-Amino-4,5-dihydrothiophenes Full article

Journal

Synlett
ISSN: 0936-5214 , E-ISSN: 1437-2096

Output data

Year: 2021, Volume: 32, Number: 09, Pages: 901-904 Pages count : 4 DOI: 10.1055/a-1385-2385

Authors

Jacob Anu ¹ , Barkawitz Philip ¹ , Andreev Ivan A. ^2,3 , Ratmanova Nina K. ² , Trushkov Igor V. ^2,3 , Werz Daniel B. ¹

Affiliations

1	Technische Universität Braunschweig, Institute of Organic Chemistry
2	Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
3	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

An easy and efficient route to obtain 2-amino-4,5-dihydrothiophenes is presented. A formal (3+2)-cycloaddition of donor–acceptor cyclopropanes and ammonium thiocyanate catalyzed by Yb(OTf)3 delivers the desired products in good to excellent yields. A broad range of functional groups is tolerated during this process.

Jacob A. , Barkawitz P. , Andreev I.A. , Ratmanova N.K. , Trushkov I.V. , Werz D.B.
(3+2)-Cycloaddition of Donor–Acceptor Cyclopropanes with Thiocyanate: A Facile and Efficient Synthesis of 2-Amino-4,5-dihydrothiophenes
Synlett. 2021. V.32. N09. P.901-904. DOI: 10.1055/a-1385-2385 WOS Scopus OpenAlex

Web of science:	WOS:000625643700001
Scopus:	2-s2.0-85102461560
OpenAlex:	W3128599388

DB	Citing
OpenAlex	24
Scopus	22
Web of science	22