A new multicomponent approach to the synthesis of substituted furan-2(5H)-ones containing 4H-chromen-4-one fragment

A new multicomponent approach to the synthesis of substituted furan-2(5H)-ones containing 4H-chromen-4-one fragment Full article

Journal

Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581

Output data

Year: 2020, Volume: 61, Number: 49, Article number : 152602, Pages count : DOI: 10.1016/j.tetlet.2020.152602

Authors

Lichitsky Boris V. ¹ , Melekhina Valeriya G. ¹ , Komogortsev Andrey N. ¹ , Minyaev Mikhail E. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr., 47, Moscow 119991, Russian Federation

An efficient telescope method for the preparation of furan-2(5H)-one derivatives containing 4H-chromen-4-one fragment was developed. The suggested approach based on tandem multicomponent reaction of 3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, arylglyoxals and Meldrum’s acid. A distinctive feature of the proposed protocol is simultaneous formation of 4H-chromen-4-one and furan-2(5H)-one fragments at one synthetic stage. The advantages of this synthesis are mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of furan-2(5H)-one derivatives was determined by X-ray diffraction.

Lichitsky B.V. , Melekhina V.G. , Komogortsev A.N. , Minyaev M.E.
A new multicomponent approach to the synthesis of substituted furan-2(5H)-ones containing 4H-chromen-4-one fragment
Tetrahedron Letters. 2020. V.61. N49. 152602 . DOI: 10.1016/j.tetlet.2020.152602 WOS Scopus OpenAlex

Web of science:	WOS:000591773500009
Scopus:	2-s2.0-85095575766
OpenAlex:	W3096108633

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OpenAlex	9
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