Novel Phenyl‐Based Bis‐quaternary Ammonium Compounds as Broad‐Spectrum Biocides

Novel Phenyl‐Based Bis‐quaternary Ammonium Compounds as Broad‐Spectrum Biocides Full article

Journal

ChemMedChem
ISSN: 1860-7179 , E-ISSN: 1860-7187

Output data

Year: 2021, Volume: 16, Number: 19, Pages: 2954-2959 Pages count : 6 DOI: 10.1002/cmdc.202100284

Authors

Frolov Nikita A. ¹ , Fedoseeva Ksenia A. ² , Hansford Karl A. ³ , Vereshchagin Anatoly N. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991,Moscow, Russian Federation
2	Mendeleev University of Chemical Technology of Russia 125047 Miusskaya square 9 Moscow Russian Federation
3	Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Herein we report the synthesis and microbiological evaluation of novel phenyl based bis-quaternary ammonium compounds (bis-QACs). Using a simple 2-step synthetic route from dibromo- and dihydroxybenzenes, we obtained a structurally diverse broad panel of bis-QACs with topologically distinct bridging connections between pyridinium heads. Selected analogs possessed potent broad-spectrum biocidal activity against both bacterial and fungal pathogens: methicillin-resistant Staphylococcus aureus (ATCC 43300); Escherichia coli (ATCC 25922), Klebsiella pneumonia (ATCC 700603), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC 90028), Cryptococcus neoformans var. grubii (ATCC 208821). Promising compounds displayed minimum inhibitory concentrations (MIC) values ≤0.25 μg/mL alongside improved cytotoxicity and hemolytic profiles compared to modern antiseptics. Thus, synthesized bis-QACs represent a promising class of biocides with the potential to replace existing household sanitizers.

Frolov N.A. , Fedoseeva K.A. , Hansford K.A. , Vereshchagin A.N.
Novel Phenyl‐Based Bis‐quaternary Ammonium Compounds as Broad‐Spectrum Biocides
ChemMedChem. 2021. V.16. N19. P.2954-2959. DOI: 10.1002/cmdc.202100284 WOS Scopus OpenAlex

Web of science:	WOS:000678101700001
Scopus:	2-s2.0-85111493486
OpenAlex:	W3181939493

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OpenAlex	8
Scopus	6