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Health-Improving Effects of Polyphenols on the Human Intestinal Microbiota: A Review Full article

Journal International Journal of Molecular Sciences
ISSN: 1661-6596 , E-ISSN: 1422-0067
Output data Year: 2025, Volume: 26, Number: 3, Article number : 1335, Pages count : DOI: 10.3390/ijms26031335
Authors Nemzer Boris V. 1,2 , Al-Taher Fadwa 2 , Kalita Diganta 2 , Yashin Alexander Y. 3 , Yashin Yakov I. 3
Affiliations
1 Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2 Department of Research & Development, VDF FutureCeuticals, Inc., Momence, IL 60954, USA
3 International Analytical Center of Zelinsky Institute of Organic Chemistry of Russian Academy of Science, Moscow 119991, Russia

Abstract: Dietary polyphenols are garnering attention in the scientific community due to their potential health-beneficial properties and preventative effects against chronic diseases, viz. cardiovascular diseases, diabetes, obesity, and neurodegenerative diseases. Polyphenols are antioxidants that change microbial composition by suppressing pathogenic bacteria and stimulating beneficial bacteria. The interaction of polyphenols with dietary fibers affects their bioaccessibility in the upper and lower parts of the digestive tract. Dietary fibers, polyphenols, their conjugates, and their metabolites modulate microbiome population and diversity. Consuming polyphenol-rich dietary fibers such as pomegranate, cranberry, berries, and tea improves gut health. A complex relationship exists between polyphenol-rich diets and gut microbiota for functioning in human health. In this review, we provide an overview of the interactions of dietary polyphenols, fibers, and gut microbiota, improving the understanding of the functional properties of dietary polyphenols.
Cite: Nemzer B.V. , Al-Taher F. , Kalita D. , Yashin A.Y. , Yashin Y.I.
Health-Improving Effects of Polyphenols on the Human Intestinal Microbiota: A Review
International Journal of Molecular Sciences. 2025. V.26. N3. 1335 . DOI: 10.3390/ijms26031335 WOS OpenAlex
Identifiers:
Web of science: WOS:001418621200001
OpenAlex: W4407151967
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