Electrophilic hexa(methoxycarbonyl)cycloheptatrienyl anion in the synthesis of electron-deficient 5-hydroxyisoquinolones

Electrophilic hexa(methoxycarbonyl)cycloheptatrienyl anion in the synthesis of electron-deficient 5-hydroxyisoquinolones Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2025, Volume: 35, Number: 2, Pages: 162-164 Pages count : 3 DOI: 10.71267/mencom.7616

Authors

Belyy Alexander Yu ¹ , Sokolova Alena D ¹ , Salikov Rinat Faritovich ¹ , Litvinenko Veronika V ¹ , Platonov Dmitry Nikolaevich ¹ , Tomilov Yury Vasil'evich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

The reaction of hexa(methoxycarbonyl)cycloheptatrienyl anion with amines affords 5-hydroxyisoquinolones bearing four 4,6,7,8-positioned methoxycarbonyl groups and having unsubstituted C3H unit. The reaction is selective due to better steric availability and both charge and orbital distribution within the seven-membered ring and may proceed through a nucleophilic attack on the allyl-anionic moiety.

Belyy A.Y. , Sokolova A.D. , Salikov R.F. , Litvinenko V.V. , Platonov D.N. , Tomilov Y.V.
Electrophilic hexa(methoxycarbonyl)cycloheptatrienyl anion in the synthesis of electron-deficient 5-hydroxyisoquinolones
Mendeleev Communications. 2025. V.35. N2. P.162-164. DOI: 10.71267/mencom.7616 WOS Scopus OpenAlex

Web of science:	WOS:001491394100013
Scopus:	2-s2.0-105007460090
OpenAlex:	W4407709804

DB	Citing
OpenAlex	2
Web of science	1
Scopus	1