Unlocking the Reactivity of the C-In Bond: Alkyl Indium Reagents as a Source of Radicals Under Photocatalytic Conditions

Unlocking the Reactivity of the C-In Bond: Alkyl Indium Reagents as a Source of Radicals Under Photocatalytic Conditions Научная публикация

Журнал

Chemical Science
ISSN: 2041-6520 , E-ISSN: 2041-6539

Вых. Данные

Год: 2025, DOI: 10.1039/d4sc08521c

Авторы

Gladkov Anton A. ^1,2 , Levin Vitalij V. ² , Cheboksarov Demian Y. ^1,2 , Dilman Alexander D. ²

Организации

1	Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory 1-3, 119991 Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prosp. 47, 119991 Moscow, Russian Federation

Generation of organic radicals from organometallic compounds is a key step in metallaphotoredox cross-coupling reactions. The ability of organoindium compounds to serve as sources of alkyl radicals under light promoted oxidative conditions is described. Organoindium reagents were used in dual photocatalytic/nickel cross-coupling with aryl bromides. These reagents can be conveniently obtained from primary, secondary and tertiary alkyl bromides and chlorides using a novel indium(I) bromide/lithium bromide system. Both steps, the formation of organoindiums and their cross-coupling are insensitive towards air and moisture and tolerate a wide variety of functional groups.

Gladkov A.A. , Levin V.V. , Cheboksarov D.Y. , Dilman A.D.
Unlocking the Reactivity of the C-In Bond: Alkyl Indium Reagents as a Source of Radicals Under Photocatalytic Conditions
Chemical Science. 2025. DOI: 10.1039/d4sc08521c WOS OpenAlex

Web of science:	WOS:001434939800001
OpenAlex:	W4407880571

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