Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands

Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2022, Volume: 32, Number: 5, Pages: 619-621 Pages count : 3 DOI: 10.1016/j.mencom.2022.09.016

Authors

Bobrova Angelina Yu. ¹ , Novikov Maxim A. ¹ , Novikov Roman A. ¹ , Dorovatovskii Pavel V. ² , Volodin Alexander D. ³ , Korlyukov Alexander A. ³ , Tomilov Yury V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	National Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation
3	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation

The key enantioselectivity-determining step in Pd-catalyzed asymmetric amination of 2-fluoroallylic substrates was optimized using model reaction of η3-(2-fluorocycloheptenyl)-palladium complexes bearing chiral P,P- and P,N-ligands with various amines. (S)-ButPHOX was found to be the most effective ligand allowing the formation of 2-fluoroallyl amines and anilines with high enantioselectivity.

Bobrova A.Y. , Novikov M.A. , Novikov R.A. , Dorovatovskii P.V. , Volodin A.D. , Korlyukov A.A. , Tomilov Y.V.
Highly enantioselective amination of η3-(2-fluorocycloheptenyl)palladium complexes bearing chiral P,P- and P,N-ligands
Mendeleev Communications. 2022. V.32. N5. P.619-621. DOI: 10.1016/j.mencom.2022.09.016 WOS Scopus OpenAlex

≡ Web of science:	WOS:000874166100016
≡ Scopus:	2-s2.0-85139337589
≡ OpenAlex:	W4302759336