The synthesis of novel 1-hetarylmethylidene-4-sulfanylfuro-[3,4-c]pyridin-3(1H)-ones

The synthesis of novel 1-hetarylmethylidene-4-sulfanylfuro-[3,4-c]pyridin-3(1H)-ones Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2022, Volume: 58, Number: 8-9, Pages: 454-461 Pages count : 8 DOI: 10.1007/s10593-022-03112-8

Authors

Kaigorodova Elena А. ¹ , Makarova Natal’ya А. ¹ , Konyushkin Leonid D. ² , Krapivin Gennady D. ³

Affiliations

1	Kuban State Agrarian University named after I. T. Tribulin, 13 Kalinina St., Krasnodar 350004, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
3	Kuban State Technological University, 2 Moskovskaya St., Krasnodar 350072, Russia

1-Hetarylmethylidene-4-sulfanylfuro[3,4-c]pyridin-3-ones were accessed from 4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one employing a condensation reaction with heteroaromatic aldehydes followed by thioalkylation, but not vice versa. Alkylation of 1-hetarylmethylidene-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-ones in an alkaline medium proceeded regioselectively at the sulfur atom to form sulfanyl derivatives.

Kaigorodova E.А. , Makarova N.А. , Konyushkin L.D. , Krapivin G.D.
The synthesis of novel 1-hetarylmethylidene-4-sulfanylfuro-[3,4-c]pyridin-3(1H)-ones
Chemistry of Heterocyclic Compounds. 2022. V.58. N8-9. P.454-461. DOI: 10.1007/s10593-022-03112-8 WOS Scopus OpenAlex

≡ Web of science:	WOS:000864239000010
≡ Scopus:	2-s2.0-85146412802
≡ OpenAlex:	W4301397380