Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates

Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates Full article

Journal

Advances in Polymer Technology
ISSN: 0730-6679 , E-ISSN: 1098-2329

Output data

Year: 2022, Volume: 2022, Article number : 6353909, Pages count : 14 DOI: 10.1155/2022/6353909

Authors

Lipaikin Sergei Y. ¹ , Yaremenko Ivan A. ² , Terent’ev Alexander O. ² , Volova Tatiana G. ^3,1 , Shishatskaya Ekaterina I. ¹

Affiliations

1	Siberian Federal University, 79 Svobodnyi av Krasnoyarsk, 660041, Russia
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp Moscow, 119991, Russia
3	Institute of Biophysics SB RAS, 50/50 Akademgorodok, Krasnoyarsk 660036, Russia

In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems.

Lipaikin S.Y. , Yaremenko I.A. , Terent’ev A.O. , Volova T.G. , Shishatskaya E.I.
Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates
Advances in Polymer Technology. 2022. V.2022. 6353909 :1-14. DOI: 10.1155/2022/6353909 WOS Scopus OpenAlex

Web of science:	WOS:000773005400001
Scopus:	2-s2.0-85127240956
OpenAlex:	W4214656565

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OpenAlex	4
Scopus	5