4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine

4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2023, Volume: 2023, Number: 3, Article number : M1700, Pages count : DOI: 10.3390/m1700

Authors

Obruchnikova Natalia V. ¹ , Rakitin Oleg A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine as a product of the Paal–Knorr reaction. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, 1H and 13C NMR, and IR spectroscopy.

Obruchnikova N.V. , Rakitin O.A.
4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine
Molbank. 2023. V.2023. N3. M1700 . DOI: 10.3390/m1700 WOS Scopus OpenAlex

Web of science:	WOS:001076792800001
Scopus:	2-s2.0-85172774722
OpenAlex:	W4384932043

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OpenAlex	Нет цитирований
Scopus	Нет цитирований