Asymmetric aldol reaction of isatins with acetone in the presence of terpene amino alcohols

Asymmetric aldol reaction of isatins with acetone in the presence of terpene amino alcohols Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2020, Volume: 30, Number: 2, Pages: 147-149 Pages count : 3 DOI: 10.1016/j.mencom.2020.03.005

Authors

Zlotin Sergei G. ¹ , Banina Olga A. ² , Sudarikov Denis V. ² , Nigmatov Albert G. ¹ , Frolova Larisa L. ² , Kutchin Alexander V. ²

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Institute of Chemistry, Komi Science Center, Ural Branch of the Russian Academy of Sciences, 167000 Syktyvkar, Russian Federation

Asymmetric aldol reactions of isatin and 4,6-dibromoisatin with acetone are efficiently catalyzed by β-amino alcohols derived from α-pinene and 3-carene. The target compounds can be isolated by crystallization from toluene, which eliminates the need for using chromatography and makes the asymmetric synthesis of (R)-convolutamydine A (up to 94% ee and yield 75%) simple and convenient.

Zlotin S.G. , Banina O.A. , Sudarikov D.V. , Nigmatov A.G. , Frolova L.L. , Kutchin A.V.
Asymmetric aldol reaction of isatins with acetone in the presence of terpene amino alcohols
Mendeleev Communications. 2020. V.30. N2. P.147-149. DOI: 10.1016/j.mencom.2020.03.005 WOS Scopus OpenAlex

Web of science:	WOS:000536145700005
Scopus:	2-s2.0-85084988297
OpenAlex:	W3026444948

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