Lewis acid catalyzed condensation of 2-aminohetarene N-oxides with N,N-dimethylformamide dimethyl acetal

Lewis acid catalyzed condensation of 2-aminohetarene N-oxides with N,N-dimethylformamide dimethyl acetal Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2021, Volume: 57, Number: 11, Pages: 1130-1136 Pages count : 7 DOI: 10.1007/s10593-021-03031-0

Authors

Karalash Sergey А. ^1,2 , Bystrov Dmitry M. ² , Ananyev Ivan V. ³ , Fershtat Leonid L. ²

Affiliations

1	Lomonosov Moscow State University, Moscow, Russia
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
3	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

A method for the introduction of the N,N-dimethylformamidine protective group in a series of six-membered 2-aminohetarene N-oxides was developed. It was shown that 2-amino derivatives of N-oxides of various six-membered heterocycles (pyridines, pyrimidines, pyrazines, tetrazines) successfully enter the reaction. The stability of the N,N-dimethylformamidine protecting group in 2-aminohetarene N-oxides was found to depend on the type of reaction medium.

Karalash S.А. , Bystrov D.M. , Ananyev I.V. , Fershtat L.L.
Lewis acid catalyzed condensation of 2-aminohetarene N-oxides with N,N-dimethylformamide dimethyl acetal
Chemistry of Heterocyclic Compounds. 2021. V.57. N11. P.1130-1136. DOI: 10.1007/s10593-021-03031-0 WOS Scopus OpenAlex

Web of science:	WOS:000737728300002
Scopus:	2-s2.0-85122237826
OpenAlex:	W4206515963

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