Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor

Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2020, Volume: 56, Number: 12, Pages: 1560-1568 Pages count : 9 DOI: 10.1007/s10593-020-02850-x

Authors

Ryzhkov Fedor V. ¹ , Ryzhkova Yuliya E. ¹ , Elinson Michail N. ¹ , Vereshchagin Anatoly N. ¹ , Korolev Victor A. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia;

Multicomponent reactions employ three or more reactants to obtain heterocycles containing fragments of all starting materials in a onepot process. All new bonds are formed at once, hence multicomponent reactions are characterized by high bond-forming index. A new multicomponent, one-pot reaction yielding previously unknown 5-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines in 52–94% yield has been found. This multicomponent approach allows to construct four new bonds to synthesize some 5H-chromeno[2,3-b]-pyridines under mild conditions. Molecular docking and dynamics studies of the synthesized structures were carried out to identify their interaction with the binding pocket of the neuropeptide Y1 receptor.

Ryzhkov F.V. , Ryzhkova Y.E. , Elinson M.N. , Vereshchagin A.N. , Korolev V.A. , Egorov M.P.
Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor
Chemistry of Heterocyclic Compounds. 2020. V.56. N12. P.1560-1568. DOI: 10.1007/s10593-020-02850-x WOS Scopus OpenAlex

Web of science:	WOS:000604795400012
Scopus:	2-s2.0-85098859514
OpenAlex:	W3120583946

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