Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD

Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD Review

Journal

Pharmaceuticals
ISSN: 1424-8247

Output data

Year: 2022, Volume: 15, Number: 9, Article number : 1100, Pages count : DOI: 10.3390/ph15091100

Authors

Kostareva Irina ¹ , Kirgizov Kirill ¹ , Machneva Elena ² , Ustyuzhanina Nadezhda ³ , Nifantiev Nikolay ³ , Skvortsova Yulia ⁴ , Shubina Irina ⁵ , Reshetnikova Vera ^6,5 , Valiev Timur ¹ , Varfolomeeva Svetlana ¹ , Kiselevskiy Mikhail ^6,5

Affiliations

1	Research Institute of Pediatric Oncology and Hematology of Nikolay Nikolayevich Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia
2	Russian Children’s Clinical Hospital of the Nikolay Ivanovich Pirogov Russian National Research Medical University, Ministry of Health of Russia, Leninsky Prospect 117, 117997 Moscow, Russia
3	Laboratory of Glycoconjugate Chemistry, Nikolay Dmitriyevich Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia
4	Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia, 1 Samory Mashela St., 117997 Moscow, Russia
5	Research Institute of Experimental Diagnostics and Therapy of Tumors of N.N. Blokhin National Medical Research Centre of Oncology, Ministry of Health of Russia, 23 Kashirskoe Shosse, 115478 Moscow, Russia
6	Center for Biomedical Engineering, National University of Science and Technology MISIS, Leninsky Prospect 4, 119049 Moscow, Russia

Despite the achievements that have increased viability after the transplantation of allogeneic hematopoietic stem cells (aHSCT), chronic graft-versus-host disease (cGVHD) remains the main cause of late complications and post-transplant deaths. At the moment, therapy alternatives demonstrate limited effectiveness in steroid-refractory illness; in addition, we have no reliable data on the mechanism of this condition. The lack of drugs of choice for the treatment of GVHD underscores the significance of the design of new therapies. Improved understanding of the mechanism of chronic GVHD has secured new therapy goals, and organized diagnostic recommendations and the development of medical tests have ensured a general language and routes for studies in this field. These factors, combined with the rapid development of pharmacology, have helped speed up the search of medicines and medical studies regarding chronic GVHD. At present, we can hope for success in curing this formidable complication. This review summarizes the latest clinical developments in new treatments for chronic GVHD.

Kostareva I. , Kirgizov K. , Machneva E. , Ustyuzhanina N. , Nifantiev N. , Skvortsova Y. , Shubina I. , Reshetnikova V. , Valiev T. , Varfolomeeva S. , Kiselevskiy M.
Novel and Promising Strategies for Therapy of Post-Transplant Chronic GVHD
Pharmaceuticals. 2022. V.15. N9. 1100 . DOI: 10.3390/ph15091100 WOS Scopus OpenAlex

≡ Web of science:	WOS:000856913500001
≡ Scopus:	2-s2.0-85138606023
≡ OpenAlex:	W4294861993