Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines

Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2022, Volume: 71, Number: 8, Pages: 1801-1805 Pages count : 5 DOI: 10.1007/s11172-022-3592-1

Authors

Serkov S.A. ¹ , Sigai N.V. ¹ , Kostikova N.N. ¹ , Fedorov A.E. ¹ , Gazieva G.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation

A general and efficient method for the synthesis of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines via cyclocondensation of aryl(benzyl)sulfanylacetic and -propionic acids with thiosemicarbazide upon their heating in POCl3 was developed. Both aryl- and benzylsulfanilacetic and -propionic acids were successfully involved in this reaction to give the target thidiazolamines in high yields (63–98%).

Serkov S.A. , Sigai N.V. , Kostikova N.N. , Fedorov A.E. , Gazieva G.A.
Synthesis and evaluation of cytotoxicity of S-substituted 5-sulfanylmethyl(ethyl)-1,3,4-thiadiazol-2-amines
Russian Chemical Bulletin. 2022. V.71. N8. P.1801-1805. DOI: 10.1007/s11172-022-3592-1 WOS Scopus OpenAlex

≡ Web of science:	WOS:000859732900026
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