A novel approach to study catalytic reactions via electrophoretic NMR on the example of Pd/NHC‐catalyzed Mizoroki–Heck cross‐coupling reaction

A novel approach to study catalytic reactions via electrophoretic NMR on the example of Pd/NHC‐catalyzed Mizoroki–Heck cross‐coupling reaction Full article

Journal

Magnetic Resonance in Chemistry
ISSN: 0749-1581 , E-ISSN: 1097-458X

Output data

Year: 2022, Volume: 60, Number: 10, Pages: 954-962 Pages count : 9 DOI: 10.1002/mrc.5295

Authors

Kulikovskaya Natalia S ¹ , Denisova Ekaterina A ¹ , Ananikov Valentine P ¹

Affiliations

1	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Investigation of catalytic reactions using nuclear magnetic resonance (NMR) is a crucial task, which is often challenging to perform due to rather complex transformations at the metal center. In this work, it was shown that electrophoretic NMR can be a suitable method for studying catalytic reactions and for observing the changes in the catalyst nature. As an important example involving palladium catalysts with N-heterocyclic carbine ligands (NHCs), the breakage of the Pd-NHC bond can occur during the catalytic process. Electrophoretic NMR allows the distinction of compounds in the spectra depending on the charge, thus bringing new opportunities to mechanistic studies. Here, we present independent evidence of R-NHC product formation in the Pd-catalyzed Mizoroki–Heck reaction—the key process for catalyst change from the molecular to nano-scale type.

Kulikovskaya N.S. , Denisova E.A. , Ananikov V.P.
A novel approach to study catalytic reactions via electrophoretic NMR on the example of Pd/NHC‐catalyzed Mizoroki–Heck cross‐coupling reaction
Magnetic Resonance in Chemistry. 2022. V.60. N10. P.954-962. DOI: 10.1002/mrc.5295 WOS Scopus OpenAlex

Web of science:	WOS:000821725300001
Scopus:	2-s2.0-85133505801
OpenAlex:	W4283267958

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