Protolytic and potential antithyroid properties of thioglycolurils and fused azolo-1,2,4-triazines

Protolytic and potential antithyroid properties of thioglycolurils and fused azolo-1,2,4-triazines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2020, Volume: 69, Number: 11, Pages: 2215-2221 Pages count : 7 DOI: 10.1007/s11172-020-3024-z

Authors

Ivolgina V.A. ¹ , Popov L.D. ¹ , Gazieva G.A. ² , Kravchenko A.N. ^2,3

Affiliations

1	Faculty of Chemistry, Southern Federal University, Rostov-on-Don, Russian Federation
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation)
3	G. V. Plekhanov Russian University of Economics, 36 Stremyannyi per., 117997 Moscow, Russian Federation

The protolytic properties and reactions with molecular iodine and blood serum proteins of 5,7-dimethyltetrahydro-1H-imidazo[4,5-e]-1,2,4-triazine-3,6(2H,4H)-dithione and (R)-1,3-dialkyl-4-[(2-hydroxybenzylidene)amino]-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones were studied. These compounds exhibit different chemical reactivities towards molecular iodine. The binding constants between these compounds and serum albumin attest to a considerable protein affinity of the compounds. The properties of the thiones make them promising as antithyroid agents.

Ivolgina V.A. , Popov L.D. , Gazieva G.A. , Kravchenko A.N.
Protolytic and potential antithyroid properties of thioglycolurils and fused azolo-1,2,4-triazines
Russian Chemical Bulletin. 2020. V.69. N11. P.2215-2221. DOI: 10.1007/s11172-020-3024-z WOS Scopus OpenAlex

≡ Web of science:	WOS:000596085400026
≡ Scopus:	2-s2.0-85097084988
≡ OpenAlex:	W3111416886