A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells

A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2020, Volume: 30, Number: 6, Pages: 750-752 Pages count : 3 DOI: 10.1016/j.mencom.2020.11.020

Authors

Gorbatov Sergey A. ^1,2 , Uvarov Denis Yu. ² , Scherbakov Alexander M. ³ , Zavarzin Igor V. ² , Volkova Yulia A. ² , Romieu Anthony ¹

Affiliations

1	Institut de Chimie Moléculaire de l’Université de Bourgogne, Université Bourgogne Franche-Comté, 21000 Dijon, France
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
3	Department of Experimental Tumor Biology, N. N. Blokhin National Medical Research Center of Oncology, 115522 Moscow, Russian Federation

The development of effective methods for real-time monitoring of nitroreductase (NTR) activity is of great significance for medical diagnosis and cancer research. Here, we present a novel water-soluble BODIPY-based chemodosimeter (NBB) for imaging the hypoxic status of human non-small-cell lung cancer A549 cells. We assume that ‘on–off’ response of NBB is activated by the NTRmediated reductive release of meso-phenol BODIPY dye resulting in unusual fluorescence.

Gorbatov S.A. , Uvarov D.Y. , Scherbakov A.M. , Zavarzin I.V. , Volkova Y.A. , Romieu A.
A novel water-soluble BODIPY dye as red fluorescent probe for imaging hypoxic status of human cancer cells
Mendeleev Communications. 2020. V.30. N6. P.750-752. DOI: 10.1016/j.mencom.2020.11.020 WOS Scopus OpenAlex

≡ Web of science:	WOS:000608614700019
≡ Scopus:	2-s2.0-85098887969
≡ OpenAlex:	W3115323907