Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography

Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2022, Volume: 32, Number: 4, Pages: 543-545 Pages count : 3 DOI: 10.1016/j.mencom.2022.07.036

Authors

Elinson Michail N. ¹ , Ryzhkova Yuliya E. ¹ , Kalashnikova Varvara M. ¹ , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

Noncatalytic on water aldol transformation of isatins and cyclic 1,3-diketones results in substituted 3-hydroxy-3-(2-hydroxy-6-oxocyclohex-1-en-1-yl)indolin-2-ones in 87–98% yields. Optimized conditions have been found and a mechanistic rationale for the reaction has been deduced. The new efficient and facile process represents a convenient way to compounds with the 3-hydroxyindolin-2-one and 3-hydroxycyclohex-2-en-1-one moieties.

Elinson M.N. , Ryzhkova Y.E. , Kalashnikova V.M. , Egorov M.P.
Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography
Mendeleev Communications. 2022. V.32. N4. P.543-545. DOI: 10.1016/j.mencom.2022.07.036 WOS Scopus OpenAlex

≡ Web of science:	WOS:000881672000036
≡ Scopus:	2-s2.0-85135414159
≡ OpenAlex:	W4289531667