H2O2/HCl system: Oxidation-chlorination of secondary alcohols to α,α′-dichloro ketones Full article
Journal |
Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581 |
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Output data | Year: 2020, Volume: 61, Number: 31, Article number : 152154, Pages count : DOI: 10.1016/j.tetlet.2020.152154 | ||||
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Abstract:
The one-pot oxidation-chlorination of secondary alcohols to give α,α′-dichloro ketones in 62–80% yields is reported. The convenient and readily available H2O2/HCl system acts on secondary alcohols (C5-C17) with the formation of α,α′-dichloro ketones. The reaction proceeds with high selectivity under the reported conditions; during this process peroxide formation and the Baeyer-Villiger oxidation reactions are not observed.
Cite:
Nikishin G.I.
, Kapustina N.I.
, Sokova L.L.
, Bityukov O.V.
, Terent'ev A.O.
H2O2/HCl system: Oxidation-chlorination of secondary alcohols to α,α′-dichloro ketones
Tetrahedron Letters. 2020. V.61. N31. 152154 . DOI: 10.1016/j.tetlet.2020.152154 WOS Scopus OpenAlex
H2O2/HCl system: Oxidation-chlorination of secondary alcohols to α,α′-dichloro ketones
Tetrahedron Letters. 2020. V.61. N31. 152154 . DOI: 10.1016/j.tetlet.2020.152154 WOS Scopus OpenAlex
Identifiers:
Web of science: | WOS:000551342800002 |
Scopus: | 2-s2.0-85087729414 |
OpenAlex: | W3036060384 |