Synthesis of 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines

Synthesis of 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2022, Volume: 71, Number: 6, Pages: 1257-1261 Pages count : 5 DOI: 10.1007/s11172-022-3527-x

Authors

Degtyarev D.D. ^1,2 , Polkovnichenko M.S. ^1,2 , Larin A.A. ¹ , Fershtat L.L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	Lomonosov Moscow State University, Department of Chemistry, Build. 3, 1 Leninskie Gory, 119991 Moscow, Russian Federation

An approach for the synthesis of the first representatives of 3,5-difuroxanyl-1,6-di-hydro-1,2,4-triazines based on the reaction of (furoxanyl)amidrazones with 4-amino-3-bromoacetylfuroxan under mild conditions was proposed. It was shown that the reaction proceeds via initial alkylation of the starting amidrazones with bromoacetylfuroxan followed by the intramolecular condensation with the formation of dihydro-1,2,4-triazine ring. Attempts to oxidize synthesized heterocyclic systems to fully aromatic derivatives under various conditions were performed.

Degtyarev D.D. , Polkovnichenko M.S. , Larin A.A. , Fershtat L.L.
Synthesis of 3,5-difuroxanyl-1,6-dihydro-1,2,4-triazines
Russian Chemical Bulletin. 2022. V.71. N6. P.1257-1261. DOI: 10.1007/s11172-022-3527-x WOS Scopus OpenAlex

Web of science:	WOS:000819001600019
Scopus:	2-s2.0-85132974237
OpenAlex:	W4283654044

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