The Influence of Adjuvants on Antigenic Properties of Peptide Constructs Composed of Hepatitis C Virus Envelope Protein E2 Fragments

The Influence of Adjuvants on Antigenic Properties of Peptide Constructs Composed of Hepatitis C Virus Envelope Protein E2 Fragments Full article

Journal

Biomedical chemistry: research and methods
ISSN: 2618-7531

Output data

Year: 2025, Volume: 8, Number: 1, Article number : e00227, Pages count : DOI: 10.18097/bmcrm00227

Authors

Egorova E.A. ^1,2 , Melnikova T.M. ³ , Melnikova M.V. ^1,4 , Zavyalova M.G. ¹ , Kostryukova L.V. ¹ , Chibiskova O.V. ¹ , Ataullakhanov R.I. ⁵ , Kolesanova E.F. ¹

Affiliations

1	Institute of Biomedical Chemistry, Moscow, Russia;
2	Sirius University of Science and Technology, Moscow, Russia
3	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
4	Research Zakusov Institute of Pharmacology, Moscow, Russia
5	National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russia

Effectiveness of the immune response in the form of the production of specific antibodies against immunogenic peptide constructs composed of conservative fragments of the hepatitis C virus envelope protein E2 depended on the adjuvants and carriers used in their preparations. The most effective formation of specific antibodies was observed in response to the injection of peptide constructs containing B- and T-epitopes of the E2 protein conjugated with a carrier with adjuvant properties, Immunomax. Antibodies obtained in response to immunization with conjugates of peptide constructs with Immunomax bound both hepatitis C virus envelope protein E2 and the heterodimer of envelope proteins E1E2.

Egorova E.A. , Melnikova T.M. , Melnikova M.V. , Zavyalova M.G. , Kostryukova L.V. , Chibiskova O.V. , Ataullakhanov R.I. , Kolesanova E.F.
The Influence of Adjuvants on Antigenic Properties of Peptide Constructs Composed of Hepatitis C Virus Envelope Protein E2 Fragments
Biomedical chemistry: research and methods. 2025. V.8. N1. e00227 . DOI: 10.18097/bmcrm00227 OpenAlex

OpenAlex:

W4408943498

Пока нет цитирований