Multicomponent Assembly of Bicyclic Aza-peroxides Catalyzed by Samarium Complexes and Their Cytotoxic Activity

Multicomponent Assembly of Bicyclic Aza-peroxides Catalyzed by Samarium Complexes and Their Cytotoxic Activity Full article

Journal

Journal of Organic Chemistry
ISSN: 1520-6904 , E-ISSN: 0022-3263

Output data

Year: 2023, Volume: 88, Number: 16, Pages: 11473-11485 Pages count : 13 DOI: 10.1021/acs.joc.3c00555

Authors

Makhmudiyarova Nataliya N. ¹ , Ishmukhametova Irina R. ¹ , Tyumkina Tatyana V. ¹ , Mescheryakova Ekaterina S. ¹ , Dzhemileva Lilya ² , D’yakonov Vladimir ² , Terent’ev Alexander O. ² , Dzhemilev Usein M. ²

Affiliations

1	Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 prospekt Oktyabrya, 450075 Ufa, Russian Federation
2	N.D. Zelinsky Institute of Organic Chemistry, 47, Leninsky prospekt, 119991 Moscow, Russian Federation

An original strategy toward bridged tetraoxazaspirobicycloalkanes was developed. The synthesis is based on a three-component condensation–cyclization reaction of primary arylamines with 1,1′-peroxybis (1-hydroperoxycycloalkanes) and pentane-1,5-dial catalyzed by Sm(NO3)3·6H2O. The structures and conformations of the products were determined by X-ray diffraction analysis and 1H and 13C NMR spectroscopy. High cytotoxic activity and biological potential toward ferroptosis induction were found for the synthesized bicyclic aza-peroxides.

Makhmudiyarova N.N. , Ishmukhametova I.R. , Tyumkina T.V. , Mescheryakova E.S. , Dzhemileva L. , D’yakonov V. , Terent’ev A.O. , Dzhemilev U.M.
Multicomponent Assembly of Bicyclic Aza-peroxides Catalyzed by Samarium Complexes and Their Cytotoxic Activity
Journal of Organic Chemistry. 2023. V.88. N16. P.11473-11485. DOI: 10.1021/acs.joc.3c00555 WOS Scopus OpenAlex

Web of science:	WOS:001045901100001
Scopus:	2-s2.0-85168325077
OpenAlex:	W4385688424

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