Effects of N-Nitropyrazoles on Ocular Blood Flow of Rabbits and Retinal Function Recovery of Rat Eyes after Ischemic Insults

Effects of N-Nitropyrazoles on Ocular Blood Flow of Rabbits and Retinal Function Recovery of Rat Eyes after Ischemic Insults Научная публикация

Журнал

Journal of Ocular Pharmacology and Therapeutics
ISSN: 1080-7683

Вых. Данные

Год: 2001, Том: 17, Номер: 6, Страницы: 505-515 Страниц : 11 DOI: 10.1089/10807680152729194

Авторы

Xuan B. ¹ , Wang T. ¹ , Chiou G.C.Y. ¹ , Dalinger I.L. ² , Shkineva T.K. ² , Shevelev S.A. ²

Организации

1	Institute of Ocular Pharmacology, and Department of Medical Pharmacology and Toxicology, Texas A&M University System Health Science Center, College Station, Texas
2	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Twelve compounds of N-nitropyrazoles were studied for their effects on ocular blood flow in rabbits and retinal function recovery in rat eyes after ischemic insults. Of the twelve N-nitropyrazoles examined, nine increased choroidal blood flow while five increased retinal blood flow significantly. On the other hand, all twelve compounds increased blood flow in iris and ciliary muscle without exception. As for retinal function recovery after ischemic insult in rat eyes, eight out of the twelve compounds showed more significant facilitation than the control. The structure activity relationship of the N-nitropyrazoles to increase ocular blood flow and to facilitate retinal function recovery after ischemic insults were discussed.

Xuan B. , Wang T. , Chiou G.C.Y. , Dalinger I.L. , Shkineva T.K. , Shevelev S.A.
Effects of N-Nitropyrazoles on Ocular Blood Flow of Rabbits and Retinal Function Recovery of Rat Eyes after Ischemic Insults
Journal of Ocular Pharmacology and Therapeutics. 2001. V.17. N6. P.505-515. DOI: 10.1089/10807680152729194 WOS Scopus OpenAlex

≡ Web of science:	WOS:000172878300002
≡ Scopus:	2-s2.0-0035672712
≡ OpenAlex:	W1978189244