Effective Electrochemical Synthesis of an Important Fungicide Tetramethylthiuram Disulfide and Its Bioactive Analogues

Effective Electrochemical Synthesis of an Important Fungicide Tetramethylthiuram Disulfide and Its Bioactive Analogues Full article

Journal

ACS Agricultural Science & Technology
ISSN: 2692-1952

Output data

Year: 2023, Volume: 3, Number: 9, Pages: 720-724 Pages count : 5 DOI: 10.1021/acsagscitech.3c00072

Authors

Mulina Olga M. ¹ , Bokova Evgeniya D. ^2,1 , Doronin Mikhail M. ¹ , Terent’ev Alexander O. ^2,1

Affiliations

1	Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russian Federation

Tetramethylthiuram disulfide (TMTD, thiram) is one of the most important fungicides and is widely used in agriculture for seed treatment and crop protection. TMTD is produced by a number of plants. Its annual sales are estimated at tens of millions of US dollars. Traditional chemical synthesis of thiram is accompanied by the formation of a significant amount of waste, including inorganic salts, thioacids, polysulfides, etc. Herein, we report an advanced method of TMTD and its structural analogues production, which is based on the usage of electric current as a key participant. Such an electrochemical approach avoids application of the chemical oxidant required for previous processes and can be efficiently scaled up. All of these characteristics make the developed synthetic method quite promising both economically and ecologically.

Mulina O.M. , Bokova E.D. , Doronin M.M. , Terent’ev A.O.
Effective Electrochemical Synthesis of an Important Fungicide Tetramethylthiuram Disulfide and Its Bioactive Analogues
ACS Agricultural Science & Technology. 2023. V.3. N9. P.720-724. DOI: 10.1021/acsagscitech.3c00072 OpenAlex

OpenAlex:

W4385932302

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