Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids

Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2023, Volume: 72, Number: 8, Pages: 1837-1843 Pages count : 7 DOI: 10.1007/s11172-023-3966-z

Authors

Serkov S.A. ¹ , Sigay N.V. ¹ , Kostikova N.N. ¹ , Tyurin A.P. ² , Kolotyrkina N.G. ¹ , Gazieva G.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997, Moscow, Russian Federation

A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating 5-substituted 1,3,4-thiadiazol-2-amines and itaconic acid under solvent-free conditions or with the addition of acetic acid at 140–150 °C. The resulting acids can be used as building blocks in the synthesis of new potentially biologically active heterocyclic compounds.

Serkov S.A. , Sigay N.V. , Kostikova N.N. , Tyurin A.P. , Kolotyrkina N.G. , Gazieva G.A.
Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids
Russian Chemical Bulletin. 2023. V.72. N8. P.1837-1843. DOI: 10.1007/s11172-023-3966-z WOS Scopus OpenAlex

≡ Web of science:	WOS:001062790500013
≡ Scopus:	2-s2.0-85169706130
≡ OpenAlex:	W4386462475