Tandem Knoevenagel-Michael reaction with oxidative cyclization in the synthesis of spiro[furo[3,2-c]pyran-2,5′ -pyrimidine] scaffold

Tandem Knoevenagel-Michael reaction with oxidative cyclization in the synthesis of spiro[furo[3,2-c]pyran-2,5′ -pyrimidine] scaffold Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2025, Volume: 35, Number: 3, Pages: 255-257 Pages count : 3 DOI: 10.71267/mencom.7660

Authors

Elinson Michail Nikolaevich ¹ , Vereshchagin Anatoly Nikolaevich ¹ , Ryzhkova Yuliya Evgenievna ¹ , Karpenko Kirill Anatol'evich ¹ , Kalashnikova Varvara Mikhailovna ¹ , Egorov Mikhail Petrovich ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

The new multicomponent one-pot tandem Knoevenagel–Michael reaction between aromatic aldehydes, N,N'-dimethylbarbituric acid, and 4-hydroxy-6-methyl-2H-pyran-2-one proceeds in alcohols at ambient temperature to selectively afford new substituted unsymmetrical spiro-[furo[3,2-c]pyran-2,5'-pyrimidine] derivatives with two different heterocyclic rings. The procedure involves available non-expensive reactants, mild and convenient conditions, does not require chromatographic isolation and provides excellent yields. The compounds thus obtained are promising for different biomedical applications.

Elinson M.N. , Vereshchagin A.N. , Ryzhkova Y.E. , Karpenko K.A. , Kalashnikova V.M. , Egorov M.P.
Tandem Knoevenagel-Michael reaction with oxidative cyclization in the synthesis of spiro[furo[3,2-c]pyran-2,5′ -pyrimidine] scaffold
Mendeleev Communications. 2025. V.35. N3. P.255-257. DOI: 10.71267/mencom.7660 WOS OpenAlex

Web of science:	WOS:001501365000004
OpenAlex:	W4409003243

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