Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model

Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model Научная публикация

Журнал

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Вых. Данные

Год: 2025, Том: 35, Номер: 3, Страницы: 274-277 Страниц : 4 DOI: 10.71267/mencom.7633

Авторы

Semenova Marina N ¹ , Kislyi Victor Petrovich ² , Maksimenko Anna Sergeevna ² , Koblov Ivan A. ² , Kuznetsov Nikita A. ² , Alisultanov Karim Narimanovich ² , Khrustalev Victor Nikolaevich ² , Samigullina Aida Ildusovna ² , Samet Alexander Viktorovich ² , Semenov Victor Vladimirovich ^2,1

Организации

1	N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation

A series of nitro analogues of potent antimitotic combretastatin A-4 (diaryl α-nitrostilbenes, DNSs) was synthesized by the Knoevenagel condensation of arylnitromethanes with methylamine Schiff bases of benzaldehydes. The obtained stilbenes featured only cis-diaryl topology irrespective of substitution pattern in the aryl fragments. The evaluation on a sea urchin embryo model suggested that DNSs exhibited both antitubulin and tubulin-unrelated effects similar to those of corresponding monoaryl nitrostyrenes.

Semenova M.N. , Kislyi V.P. , Maksimenko A.S. , Koblov I.A. , Kuznetsov N.A. , Alisultanov K.N. , Khrustalev V.N. , Samigullina A.I. , Samet A.V. , Semenov V.V.
Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model
Mendeleev Communications. 2025. V.35. N3. P.274-277. DOI: 10.71267/mencom.7633 WOS Scopus OpenAlex

Web of science:	WOS:001501365000011
Scopus:	2-s2.0-105006817613
OpenAlex:	W4409003247

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